USPTO Patents Application 10687850

WORLD INTELLECTUAL PROPERTY ORGANIZATION
International Bureau

PCT

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)

(51) International Patent Classification 6 :
G01N 33/487, A61B 5/00

Al

(11) International Publication Number:
(43) International Publication Date:

WO 99/22236

6 May 1999 (06.05.99)

(21) International Application Number: PCT/FI98/00740

(22) International Filing Date: 22 September 1998 (22.09.98)

(30) Priority Data:
974065

27 October 1997 (27.10.97)

FI

(71) Applicant (for all designated States except US): NOKIA MO-

BILE PHONES LTD. [FI/FI]; Keilalahdentie 4, FIN-02150
Espoo (FI).

(72) Inventors; and

(75) Inventors/Applicants (for US only): HEINONEN, Pekka
[FI/FI]; Hakakuja 2 B 28, FIN-O2100 Espoo (FI). OKKO-
NEN, Ham [FI/FI]; Salonkitie 5 as. 3, FIN-02940 Espoo
(FI). BERG, Jukka [FI/FI]; Perhotie !, FIN-90550 Oulu
(FI).

(74) Agent: JOHANSSON, Folke; Nokia Mobile Phones Ltd., P.O.
Box 100, FIN-00045 Nokia Group (FI).

(81) Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR,
BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD,
GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR,
KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN,
MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK,
SL, TJ, TM, TO, TT, UA, UG, US, UZ, VN, YU, ZW,
ARIPO patent (GH, GM, KE, LS, MW, SD, SZ, UG, ZW),
Eurasian patent (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM),
European patent (AT, BE, CH, CY, DE, DK, ES, FI, FR,
GB, GR, IE, IT, LU, MC, NL, PT, SE), OAPI patent (BF,
BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN,
TD, TG).

Published

With international search report.

(54) Title: CALIBRATION OF MEASURED PHYSICAL PARAMETERS

(57) Abstract

A system for measuring the blood glucose level in a sample of a patient's blood. Consumable test strips (5) are provided together with
a code (7) which identifies the manufacturing batch of the strip (5). A measurement unit (2) is provided and is coupled to a mobile telephone
(1). The measurement unit (2) is arranged to receive a test strip (5) and to determine a colour change in a reagent (4) due to reaction of
the reagent (4) with a blood sample. The identification code (7) is read at the same time by the measurement unit (3) and is transmitted by
the mobile telephone (1) to a central database (9) provided by the test strip manufacturer. The database (9) contains identification codes
(7) together with associated calibration data. Upon receipt of an identification code (7) the remote database (9) transmits the associated
calibration data to the mobile telephone (1) which uses the calibration data to calculate a test result from the measured change in colour.
The result can be displayed to the patient on a display of the telephone (1).

FOR THE PURPOSES OF INFORMATION ONLY
Codes used to identify States party to the PCT on the front pages of pamphlets publishing international applications under the PCT.

AL

Albania

ES

Spam

LS

Lesotho

SI

Slovenia

AM

Armenia

FI

Finland

LT

Lithuania

SK

Slovakia

AT

Austria

FR

France

LU

Luxembourg

SN

Senegal

AU

Australia

GA

Gabon

LV

Latvia

sz

Swaziland

AZ

Azerbaijan

GB

United Kingdom

MC

Monaco

TD

Chad

BA

Bosnia and Herzegovina

GE

Georgia

MD

Republic of Moldova

TG

Togo .

BB

Barbados

GH

Ghana

MG

Madagascar

TJ

Tajikistan

BE

Belgium

GN

Guinea

MK

The former Yugoslav

TM

Turkmenistan

BF

Burkina Faso

GR

Greece

Republic of Macedonia

TR

Turkey

BC

Bulgaria

HU

Hungary

ML

Mali

TT

Trinidad and Tobago

BJ

Benin

IE

Ireland

MN

Mongolia

UA

Ukraine

BR

Brazil

IL

Israel

MR

Mauritania

UG

Uganda

BY

Belarus

IS

Iceland

MW

Malawi

US

United States of America

CA

Canada

IT

Italy

MX

Mexico

uz

Uzbekistan

CF

Central African Republic

JP

Japan

NS

Niger

VN

Viet Nam

CG

Congo

KB

Kenya

NL

Netherlands

YU

Yugoslavia

CH

Switzerland

KG

Kyrgyzstan

NO

Norway

ZW

Zimbabwe

CI

Cdte d'lvoire

KP

Democratic People's

NZ

New Zealand

CM

Cameroon

RepobSc of Korea

PL

Poland

CN

China

KR

Republic of Korea

PT

Portugal

cu

Cuba

KZ

Kazakstan

RO

Romania

cz

Czech Republic

IX

Saint Lucia

RU

Russian Federation

DE

Germany

U

Liechtenstein

SB

Sudan

DK

Denmark

LK

Sri Lanka

SE

Sweden

EE

Estonia

LR

Liberia

SG

Singapore

WO 99/22236

PCT/FI98/00740

1

CALIBRATION OF MEASURED PHYSICAL PARAMETERS

The present invention relates to measurement apparatus and in particular to
measurement apparatus which makes use of a consumable reagent in a measuring
5 process.

There are many examples of measurement apparatus which make use of a consumable
reagent as part of a measuring process. Consumable reagents are generally of a
chemical, biochemical, or biological nature. One example of such an apparatus is a blood

10 glucose meter designed to measure the level of glucose in a sample of a patient's blood.
A small amount of a suitable reagent is printed or otherwise deposited onto an elongate
plastic strip which can be inserted into the blood glucose meter. The meter comprises a
reflectometry based measuring system which detects a change in the colour of the printed
reagent due to a reaction between the active reagent and glucose present in the blood

15 sample.

It will be appreciated that in the case of a blood glucose meter, where a patient
determines an insulin treatment regime on the basis of blood glucose measurements, the
accuracy of the meter is critical. This requires very precise calibration of the meter. Initial

20 calibration of the meter is normally carried out during and immediately following

manufacturing, with certain calibration data being stored in permanent memory of the
meter. However, calibration of the meter at this stage cannot easily account for changes
and variations in the properties of the consumable reagents themselves, variations which
might arise due to slight changes in the manufacturing process of the reagent and the

25 test strip, environmental factors such a temperature and humidity, and changes in the
property of the reagent over time.

It is known to provide blood glucose test strips, or rather a pack of such test strips, with a
machine readable memory in which calibration data is stored. When a new pack of test

30 strips is opened, the machine readable memory is read by the meter and calibration data
downloaded into the memory of the blood glucose meter. In this way it is possible to take
account of reagent manufacturing variations in the calibration of the meter. However, it
will be appreciated that providing a machine readable memory with each packet of test
strips is relatively expensive both in terms of the hardware required and in terms of the

35 additional time required to program the memory during the manufacturing process.

WO 99/22236

PCT/FI98/00740

2

In addition, it remains difficult to account for changes in the properties of a reagent over
time. At best, only a poor estimate can be made based upon some predetermined criteria
and only then if the age of the reagent is known. As such, manufacturers of blood
glucose test strips tend to supply test strips in very limited numbers and make tight
5 specifications for storage and lifetime to ensure that the properties of the reagents remain
within desired limits. These specifications tend to work against economies of scale in the*
manufacturing and distribution of test strips.

These problems are not limited to blood glucose test strips and apply equally to other
1 0 fields in which consumable reagents are used.

According to a first aspect of the present invention there is provided a measurement
system comprising:

measurement apparatus for measuring a physical parameter using a consumable
15 reagent, said reagent having an identification code associated therewith;
automatic telephone answering means;

a database coupled to the automatic telephone answering means and containing a
set of consumable reagent identification codes and respective calibration data;

means for coupling the measurement apparatus to the automatic telephone
20 answering means via a telephone link,

the automatic telephone answering means being arranged to receive an
identification code transmitted from the measurement apparatus over said telephone link,
to subsequently access said database to identify the calibration data associated with said
transmitted identification code, and to either transmit the identified calibration data to the
25 measurement apparatus, or to calculate a test result using the identified calibration data
and transmit the test result to the measurement apparatus.

By storing the calibration data for specific consumable reagents at a central database, it is
possible to update the calibration data to reflect changes which may occur to the

30 consumable reagents over time. Furthermore, it is no longer necessary to supply the
calibration data to the end user with the reagents. This simplifies the manufacturing
process and also eliminates the need to supply complex memory means to the end user.
A further advantage of the present invention is that data generated by the measurement
apparatus using the consumable reagent can be transmitted to the central database

35 where information from many apparatus can be collected and analysed.

WO 99/22236

PCT/FI98/00740

3

In one embodiment of the present invention, the automatic telephone answering means is
arranged to transmit calibration data associated with the received identification code back
to the measurement apparatus. The measurement apparatus comprises data processing
means for processing said measured physical parameter, using the received calibration
5 data, to provide a test result Preferably, the measurement apparatus comprises a
display for displaying the test result to a user.

In an alternative embodiment of the present invention, the measurement apparatus is
arranged to transmit said measured physical parameter to the automatic telephone

1 0 answering means together with said identification code. The system further comprises
data processing means, coupled to the database and the automatic telephone answering
means, for calculating a test result using the identified calibration data and the received
physical parameter. The automatic telephone answering means is arranged to transmit
the test result back to the measurement apparatus, e.g. for display on a display of the

15 apparatus. An advantage of this embodiment is that it is possible to use relatively
complex algorithms to compute the test result due to the relatively high processing
capability which can be provided at a central facility. Furthermore, the algorithm can be
easily updated or modified.

20 Preferably, the identification code is provided with the consumable reagent in a machine
readable form. For example, the code may be contained in a bar-code or in a solid state
memory. The measurement apparatus is provided with a machine reader which is
capable of reading the identification code into a memory of the measurement apparatus.
An identification code may be provided with each individual consumable reagent or may

25 be provided with a batch of such units. Where the consumable reagents are provided on
a test strip, the code may be provided on one such test strip or on a dummy strip.

In an alternative embodiment, the identification code is provided in a human readable
form. The measurement apparatus comprises a user interface for allowing the user to
30 enter the identification code. For example, the user interface may be a keypad.

The measurement apparatus may comprise mobile telephone apparatus which is able to
connect the measurement apparatus to the database via a wireless transmission channel.
A measurement unit of the apparatus may be integral with said mobile phone or may be
35 connectable thereto. Data may be transmitted between the mobile telephone apparatus
and the automatic telephone answering means via a data call. In the case that the mobile

WO 99/22236

PCT/FI98/00740

4

telephone apparatus is a digital telephone apparatus according to the GSM system, the
data may be transmitted using the short messaging system (SMS).

The present invention is applicable, for example, to a system for measuring the glucose
5 level in a sample of a patient's blood.

According to a second aspect of the present invention there is provided a consumable
reagent, or a pack of consumable reagents, in combination with an identification code,
said reagent(s) being for use with the measurement system of the above first aspect of
10 the present invention, where said identification code identifies a set of calibration data
stored in said database.

Preferably, the combination of the second aspect of the present invention comprises a
machine readable memory by means of which said identification code is stored. The
1 5 memory may be a bar code, memory chip, magnetic strip, or any other suitable means.

According to a third aspect of the present invention there is provided a method of deriving
a test result from a physical parameter measured using a measurement apparatus and a
consumable reagent, the method comprising;
20 providing a consumable reagent together with an identification code;

providing a database containing a set of identification codes and respective
calibration data;

transmitting said identification code from the measurement apparatus to the
database via a telephone link; and
25 automatically responding to receipt of the transmitted identification code by

identifying the corresponding calibration data in the database, and transmitting that data,
or a test result determined using the data, back to the measurement apparatus.

Preferably, said telephone link comprises a mobile telephone link, wherein the
30 measurement apparatus comprises a measurement unit coupled to mobile telephone
apparatus.

For a better understanding of the present invention and in order to show how the same
may be carried into effect reference will now be made, by way of example, to the
35 accompanying drawings, in which:

Figure 1 shows a measurement system embodying the present invention; and

WO 99/22236

PCT/FI98/00740

5

Figure 2 is a flow diagram illustrating a measurement method implemented by the
system of Figure 1.

There is shown in Figure 1 a system which is capable of providing a diabetic patient with
a blood glucose level test result. The system comprises a mobile telephone 1 which is
shown from the rear in Figure 1 and in which the keyboard and display are not visible. .
jhe telephone comprises modified software but is otherwise conventional. However, in
place of the conventional battery, a measurement unit 2 is provided which can be inserted
into the slot on the rear of the mobile phone 1 normally occupied by the battery. The
measurement unit 2 contains a reduced size battery unit (not shown) for powering the
measurement unit 2 and the phone 1 .

The measurement unit 2 contains an internally arranged reflectometry system 3 which is
operable to measure the colour change in a consumable reagent 4 relative to some
predetermined base level. The consumable reagent 4 is printed, or otherwise deposited,
on a surface region of an elongate test strip 5. The test strip 5 is insertable into a slot 6
provided in the side of the measurement unit 2 and which provides access to the
reflectometry system 3.

In addition to the consumable reagent 4, the test strip 5 is provided with a barcode 7
printed on its upper surface. The barcode 7 represents an identification code which
identifies the manufacturing batch number of the test strip 5. The measurement unit 2
contains an optical reader, aligned with the slot 6, which reads the barcode 7 when the
test strip 5 is inserted into the slot 6. The optical reader may be an independent internal
component of the measurement unit 2, but is preferably provided, at least in part, by the
reflectometry system 3. In either case, the read identification code is stored in a memory
8 of the measurement unit 2 or of the telephone 1 .

The manufacturer or distributor of the test strips 5 maintains a central database 9
containing a set of identification codes, each of which uniquely identifies an individual
manufacturing batch of test strips 5. Associated with each identification code is a set of
calibration data. This calibration data typically includes an offset value and a scaling
factor which can be used to relate a measured colour change to a blood glucose level
(non-linear calibration data may also be provided). Calibration data for a batch of test
strips is initially determined following manufacture of a batch, for example by comparing
the results of a test carried out using a typical measurement unit and by laboratory

WO 99/22236

PCT/FI98/00740

6

analysis. The calibration data however is updated at regular time intervals by re-testing
samples taken from a retained test strip stock.

An automatic telephone answering device 10 is located at the manufacturer's (or
5 distributor's) premises and is coupled to both a telephone line 1 1 and to the database 9.
The operation of this device 10 is described below.

To initiate a blood glucose test, the patient activates a measurement sequence using a
menu displayed on the phone's display. The patient then deposits a small amount of
1 0 blood on top of the reagent 4. After a short time, the test strip 5 is fully inserted into the
slot 6. Upon insertion, the identification code conveyed by the barcode 7 is read into the
unit's memory 8. The colour change in the reagent 4 is then determined by the
reflectometry system 3 and the result also read into the unit's memory 8.

1 5 The patient is then prompted, by a message displayed on the telephone's display, to
initiate a data call to the remote automatic telephone answering device 10. Following
acceptance of the prompt by the user, the telephone 1 opens a data channel with a
cellular telephone 12 network and transmits the read identification code to the automatic
telephone answering device 10 via the telephone line 11. The answering device 10

20 responds by accessing the database 9 and downloading therefrom the calibration data
corresponding to the received identification code. The answering device 10 then formats
the calibration data and transmits it back to the mobile telephone 1 via the cellular
network 12.

25 The calibration data received by the telephone 1 is stored in the memory 8. The

telephone then proceeds to calculate a blood glucose test result using the measured
colour change, the received calibration data, and a calculation algorithm which is pre-
stored in the measurement unifs memory 8. This calculation is carried out by a central
processing unit 1 3 of the phone 1 .

30

The main steps associated with the measurement process at the measurement apparatus
are shown in the flow diagram of Figure 2.

It will be appreciated that the same result can be obtained by transmitting the measured
35 colour change from the measurement unit 2 and the mobile telephone 1 , to the remote
database 9, together with the identification code. The database 9 can then process the

WO 99/22236

PCT/FI98/00740

7

measured value using the calibration data to generate a test result. It is then not
necessary to transmit the calibration data to the measurement unit 2 and only the test
result needs to be transmitted. The result received by the mobile telephone 1 can then be
displayed directly on the telephone's display.

5

In addition to providing the measurement unit with the most up to date calibration data,. ■
the system described above provides a number of other significant advantages. For
example, if a user mistakenly tries to use a test strip which has passed its 'use by* date,
the user can be notified of this, and the measurement blocked, by the database and the
1 0 automatic answering device. Accurate records can also be kept, by the database, of the
usage pattern of test strips.

It will be appreciated that modifications may be made to the above described embodiment
without departing from the scope of the present invention. For example, whilst the
15 embodiment described above makes use of a mobile telephone, alternative embodiments
may use land line telephones or two-way pagers.

WO 99/22236

PCT/FI98/00740

8

Claims

1 . A measurement system comprising:

measurement apparatus (1,2) for measuring a physical parameter using a
5 consumable reagent (4), said reagent having an identification code (7) associated
therewith;

automatic telephone answering means (10);

a database (9) coupled to the automatic telephone answering means (10) and
containing a set of consumable reagent identification codes and respective calibration
10 data;

means (1) for coupling the measurement apparatus to the automatic telephone
answering means (1) via a telephone link (1 1 ,12),

the automatic telephone answering means (1 0) being arranged to receive an
identification code transmitted from the measurement apparatus (1 ,2) over said telephone
1 5 link (1 1 ,12), to subsequently access said database (9) to identify the calibration data
associated with said transmitted identification code, and to either transmit the identified
calibration data to the measurement apparatus (1 ,2), or to calculate a test result using the
identified calibration data and transmit the test result to the measurement apparatus (1,2).

20 2. A system according to claim 1 , wherein the automatic telephone answering means
(10) is arranged to transmit calibration data associated with the received identification
code back to the measurement apparatus (1 ,2) and the measurement apparatus (1 ,2)
comprises data processing means (13) for processing said measured physical parameter,
using the received calibration data, to provide a test result.

25

3. A system according to claim 1 , wherein the measurement apparatus (1 ,2) is
arranged to transmit said measured physical parameter to the automatic telephone
answering means (10) together with said identification code, the system further
comprising data processing means (9), coupled to the database (9) and the automatic
30 telephone answering means (10), for calculating a test result using the identified

calibration data and the received physical parameter, the automatic telephone answering
means (10) being arranged to transmit the test result back to the measurement apparatus
(1,2).

35 4. A system according to any one of the preceding claims, wherein the identification
code is provided with the consumable reagent (4) in a machine readable form (7).

WO 99/22236

PCT/FI98/00740

9

5. A system according to claim 4, wherein the identification code (7) is contained in a
bar-code or in a solid state memory and the measurement apparatus (1 ,2) is provided
with a machine reader (3) which is capable of reading the identification code into a

5 memory (8) of the measurement apparatus (1 ,2).

6. A system according to any one of the preceding claims, wherein the measurement
apparatus (1,2) comprises mobile telephone apparatus (1) which is able to connect the
measurement apparatus (1 ,2) to the database (9) via a wireless transmission channel

10 (12).

7. A system according to any one of the preceding claims, wherein the measurement
apparatus (1 ,2) is arranged to provide a measure of the glucose level in a sample of a
patient's blood.

15

8. A consumable reagent (4), or a pack of consumable reagents, in combination with
an identification code (7), said reagent(s) (4) being for use with the measurement system
of any one of the preceding claims, where said identification code (7) identifies a set of
calibration data stored in said database (9).

20

9. The combination of claim 8, comprising a machine readable memory by means of
which said identification code (7) is stored.

10. A method of deriving a test result from a physical parameter measured using a
25 measurement apparatus and a consumable reagent, the method comprising;

providing a consumable reagent together with an identification code;
providing a database containing a set of identification codes and respective
calibration data;

transmitting said identification code from the measurement apparatus to the
30 database via a telephone link; and

automatically responding to receipt of the transmitted identification code by
identifying the corresponding calibration data in the database, and transmitting that data,
or a test result determined using the data, back to the measurement apparatus.

WO 99/22236 PCT/FI98/00740

10

11. A method according to claim 10, said telephone link comprising a mobile
telephone link, wherein the measurement apparatus comprises a measurement unit
coupled to mobile telephone apparatus.

WO 99/22236

PCT/FI98/00740

1/2

Figure 1

WO 99/22236

PCT/FI98/00740

2/2

Select measurement
mode

Insert test
strip

Read barcode and
perform reflectance
measurement

Initiate data call to remote
database and transmit ID code

Receive calibration
parameters

Process measured reflectance
and display blood glucose level

Figure 2

INTERNATIONAL SEARCH REPORT

International application No.

PCT/FI 98/00740

A. CLASSIFICATION OT SUBJECT MA'ITKR

IPC6: G01N 33/487, A61B 5/00

According to International Patent Classification (IPC) or lo hoih national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols)

IPC6: A61B, G01N

Documentation searched other than minimum documentation to ihc extent that such documents are included in the fields searched

SE,DK,FI,N0 classes as above

Electronic data base consulted during the international search (name of data base and, where practicable, search terms used)

wpi

C. DOCUMEN TS CONSIDERED TO BE RELEVANT

Category*

Glation of document, with indication, where appropriate, of the relevant passages

Relevant to claim No.

A

Patent Abstracts of Japan, abstract of JP

6-350726 A (NISHITOMO: KK), 22 December 1994
(22.12.94)

1-11

A

EP 0807805 A2 (SOEHNLE-WAAGEN GMBH + CO), 9 May
1997 (09.05.97), abstract

1-11

A

US 5507288 A (DIRK B6CKER ET AL), 16 April 1996
(16.04.96), column 4, line 36 - line 43

1-11

A

US 4706207 A (JEMES W. HENNESSY ET AL),

10 November 1987 (10.11.87), column 15,
line 4 - line 13

1-11

| xl Further documents are listed in the continuation of Box C | )(j Sec patent family annex.

* Special categoric* of cited document*

* A" document defining the general slate of the art which ix not considered

to be of particular relevance
"E" erlier document but published on or after ihc international fifing dale

"1/ document which may throw doubts on priority d«m(s) <ir which is
cited to establish the publication dale of another citation or other
special reason (as specified)

"O" document referring to an oral disclosure, use, exhibition or other
means

"P* document published prior to the international filing date hut later than
the priority date daimed

later document puhlished after the tntcrnabonal filing date or priority
date and not in conflict with the application but died lo understand
the prindpte or theory underlying the invention

document of particular relevance: the daimed invention cannot be
considered novel or cannot be ctmndcrcd to involve an inventive
.'step when the document is taken alone

document of particular relevance the daimed invention cannot be
considered lo involve an inventive step when the document is
combined with one or more other such documents, such combination
bong obvious lo a person skilled in the art

document member of the same patent family

Date of the actual completion of the international search

15 February 1999

Date of mailing of the international search report

1 7 -02- 1999

Name and mailing address of the ISA/
Swedish Patent Office
Box 5055, S-102 42 STOCKHOLM
Facsimile No. + 46 8 666 02 86

Authorized officer

Mai in Keijser

Telephone No. - + 46 8 782 25 00

Form PCT/ISA/2I0 (second sheet) (July 1992)

INTERNATIONAL SEARCH REPORT

International application No.

PCT/FI 98/00740

C (Continuation). DOCUMENTS CONSIDERED TO BR RELEVANT

Category*

Citation of document, with indication, where appropriate, of the relevant passages

Relevant to claim No.

A

WO 9708544 Al (ANDCARE INC), 6 March 1997
(06.03.97), page 5, line 4 - line 29

i-ii

Form PCT/ISA/210 (continuation of second sheet) {July 1992)

INTERNATIONAL SEARCH REPORT

Information on patent family members

02/02/99

International application No.

PCT/FI 98/00740

Patent document
cited in search report

Publication
date

Patent family
member(s)

Publication
dale

EP 0807805 A2 09/05/97 DE 19619854 A 20/11/97

US 5507288 A

16/04/96

AU

674474 B

19/12/96

AU

1763495 A

07/12/95

CA

2148569 A

06/11/95

CN

1128353 A

07/08/96

DE

4415896 A

09/11/95

EP

0680727 A

08/11/95

FI

952131 A

06/11/95

HU

75243 A

28/05/97

HU

9501274 0

00/00/00

IL

113569 A

04/01/98

JP

7311196 A

28/11/95

NO

951754 A

06/11/95

NZ

272000 A

24/04/97

US

4706207

A

10/11/87

EP

0228453 A

15/07/87

JP

63500398 T

12/02/88

WO

8700280 A

15/01/87

WO

9708544

Al

06/03/97

AU

6904496 A

19/03/97

Form PCr/ISA/210 (patent family annex) (July 1992)